Paediatr Anaesth. 2019 Mar 25. doi: 10.1111/pan.13634. [Epub ahead of print]
1. Department of Anesthesia, Intensive care and Pain Management, AP-HP, Robert Debré University Hospital., Paris, France.
2. Paris Diderot University (Paris 7). Pres Paris Sorbonne Cité., Paris, France.
3. DHU PROTECT, RobertDebré University Hospital, Paris, France.
Since the withdrawal of codeine in children, rescue analgesia is usually usually performed using tramadol. This compound is metabolized (by the P2D6 cytochrome the same enzyme that transforms codeine to morphine) to the O-Demethyl tramadol, a compound 20 times more potent than morphine (1). Cases of respiratory depression have been observed in patients receiving tramadol. This article is protected by copyright. All rights reserved.